Stabilization Provided by Neighboring Strands Is Critical for the Mechanical Stability of Proteins
نویسندگان
چکیده
منابع مشابه
Stabilization provided by neighboring strands is critical for the mechanical stability of proteins.
Single-molecule force spectroscopy studies and steered molecular dynamics simulations have revealed that protein topology and pulling geometry play important roles in determining the mechanical stability of proteins. Most studies have focused on local interactions that are associated with the force-bearing beta-strands. Interactions mediated by neighboring strands are often overlooked. Here we ...
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Mechanical stability of proteins.
A number of experiments and experimentally based simulations showed that beta-proteins are mechanically more stable than alpha-proteins. However, the theory that might explain this evidence is still lacking. In this paper we have developed a simple elastic theory, which allows to estimate critical forces for stretching both kinds of proteins. It has been shown that unfolding of beta-proteins do...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2008
ISSN: 0006-3495
DOI: 10.1529/biophysj.108.134072